Tim Wakefield, a longtime knuckleball pitcher and two-time World Series champion, died Sunday at the age of 57 from brain cancer, the Boston Red Sox announced.

"Our hearts are broken with the loss of Tim Wakefield," the Red Sox said on social media. "Wake embodied true goodness; a devoted husband, father, and teammate, beloved broadcaster, and the ultimate community leader. He gave so much to the game and all of Red Sox Nation."

A 19-year MLB veteran, Wakefield started his career in 1992 with the Pittsburgh Pirates, but is known for his time in Boston, where he spent the last 17 years of his career. The knuckleballer was a mainstay on the Red Sox pitching staff, going from starter to reliever throughout his tenure in Boston. He was part of the 2004 and 2007 World Series-winning teams, and made the All-Star Game in 2009. He also was awarded the Roberto Clemente Award in 2010.

Wakefield retired in 2012 and finished his career with 200 wins, 180 losses and 22 saves. He finished with a career ERA of 4.41, and his 186 wins in Boston ranks third in franchise history behind Roger Clemens and Cy Young.

"Tim’s kindness and indomitable spirit were as legendary as his knuckleball," Red Sox principal owner John Henry said in a statement. "He not only captivated us on the field but was the rare athlete whose legacy extended beyond the record books to the countless lives he touched with his warmth and genuine spirit. He had a remarkable ability to uplift, inspire, and connect with others in a way that showed us the true definition of greatness. He embodied the very best of what it means to be a member of the Boston Red Sox and his loss is felt deeply by all of us."

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After retiring, Wakefield became an announcer for the Red Sox, while remaining active in Boston charities, and was inducted into the team’s Hall of Fame in 2016.

The Red Sox recently announced Wakefield was undergoing treatment for an unspecified disease after his illness was outed without his consent by ex-teammate Curt Schilling.

Wakefield is survived by his wife, Stacy, and their children, Trevor and Brianna.