INGLEWOOD, Calif. – Patrick Mahomes and the Kansas City Chiefs were backed up on their own eight-yard line. On third-and-6, the Chiefs needed a first down to ice the game late in the fourth quarter. Xavier Worthy ran a shallow cross across the middle and Mahomes hit the speedy wide receiver in stride for 15 yards to preserve the 17-10 win versus the Los Angeles Chargers.

The big-time game-sealing first-down catch is precisely what Kansas City needs from their now depleted Chiefs wide receiving corps going forward.

Kansas City improved to 4-0 on Sunday. Yet, the back-to-back Super Bowl champions were dealt a significant blow in the process.

“Rashee Rice will have his knee checked out (Monday) with an MRI,” Chiefs coach Andy Reid said postgame. “I’m sure it’s not as good as we want.”

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Rice injured his right knee while trying to tackle Chargers cornerback Kristian Fulton following an interception by Patrick Mahomes in the first quarter. As Rice went in for the tackle, Mahomes inadvertently collided with the wideout as he attempted to take down Fulton.

After the play, Rice was helped off to the sideline and eventually carted off the to the locker room. The Chiefs ruled Rice out of the game in the first half.

“I was trying to fire it to Travis (Kelce) on his body. I overthrew him a little bit. I turned the ball over,” Mahomes said of the play that injured Rice. “I thought Rashee made a really good play. I was trying to tackle the guy, and obviously rolled up on him, but if I just don’t turn the ball over that never happens.”

The Chiefs aren’t expecting positive MRI results on Rice’s knee.

“Guys all hung together. I feel terrible for Rashee,” Reid said. “He’s having a fantastic year.”

Rice came into Week 4 with an NFL-high 24 catches. He was the team leader in both catches and receiving yards (288). He emerged early on this year at the team’s top pass catcher, even ahead of veteran tight end Travis Kelce. Rice's absence could be a crippling blow in Kansas City’s quest for an historic third straight Super Bowl victory. The team is already without running back Isiah Pacheco and wide receiver Marquise "Hollywood" Brown.

But the Chiefs have won four straight one-score games to start the regular season and 10 in a row dating back to last year. They find ways to win with Reid’s play calling, the best quarterback in the NFL and the only tight end in NFL history to have seven-straight 1,000-yard seasons (2016-22) in Kelce.

The Mahomes-Kelce connection was rekindled on Sunday. Kelce, who’s had a quiet start to the year by his standards, was targeted nine times and the tight end produced a season-high seven catches for 89 yards when the Rice-less Chiefs offense needed a go-to target.

“With Rashee going out early, you got to put Kelce back in that situation where he’s getting high-volume catches,” Mahomes said. “The whole Kelce thing in general hasn’t been a worry to me. I know whenever we need him, he’s going to make plays.”

Kelce will presumably continue to get “high-volume” targets in Rice’s absence. However, Worthy might emerge as the go-to wide receiver. Worthy amassed three catches, 73 yards and a touchdown in the win, including a 54-yard touchdown reception. The speedster told USA TODAY Sports that the Chiefs are an ideal fit for him. Now is an opportune time to demonstrate that.

“In our receiving room it’s next man up,” Worthy said. “Praying for our brother. But I feel like we have a lot of guys that’s able to make plays in key moment.”

Without Rice, the next man up in the receiving room figures to be Worthy.

Kansas City’s passing attack will need its veteran tight end, and their rookie first-round pick wide receiver to continue to make plays if they hope to have a chance to be the first NFL team ever to three-peat as Super Bowl champions.

Follow USA TODAY Sports' Tyler Dragon on X @TheTylerDragon.