Injuries continue to hit the NFL hard in 2024, with multiple star fantasy football players missing time early on this season. With four more teams on a bye this week — Kansas City, Minnesota, Miami, and the Los Angeles Rams — player availability is key.

Here's what we know about injured fantasy football players ahead of Week 6.

Fantasy football injury report: Week 6

RB Devin Singletary, New York Giants: Questionable (groin)

The Giants' leading rusher missed Week 5 due to a groin injury and was limited in practice on Wednesday. He did practice last Friday in a limited capacity as well.

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WR Malik Nabers, New York Giants: Questionable (concussion)

Nabers missed the Giants' Week 5 win over Seattle as he goes through the concussion protocol. He still hasn't been cleared and did not practice with the team on Wednesday.

RB Zack Moss, Cincinnati Bengals: Questionable (foot)

Moss left Cincinnati's Week 5 loss to Baltimore with an injury and did not practice on Wednesday.

TE Mike Gesicki, Cincinnati Bengals: Questionable (hamstring)

Gesicki did not practice Wednesday after notching two catches for 31 yards in Week 5. This is the first time he's appeared on the injury report since Week 3; he hasn't missed any playing time so far.

WR Diontae Johnson, Carolina Panthers: Questionable (ankle)

Johnson was listed on the injury report last week but still played against Chicago. This could be something similar after he practiced in a limited fashion Wednesday.

WR Darnell Mooney, Atlanta Falcons: Questionable (knee)

Mooney was limited in practice Wednesday. His status remains uncertain but his practice participation could ramp up during the week.

RB Zamir White, Las Vegas Raiders: Questionable (groin)

White missed last week's loss to the Broncos and did not practice again on Wednesday. His status remains up in the air with Alexander Mattison set to start in his place if needed.

WR Jakobi Meyers, Las Vegas Raiders: Questionable (ankle)

Meyers — the Raiders' top wide receiver with Davante Adams out — did not practice Wednesday. He played nearly every snap in Week 5 and that gives confidence he should be back in action in Week 6.

RB Cordarrelle Patterson, Pittsburgh Steelers: Out (ankle)

After playing well against the Colts in Week 4, Patterson missed last week's loss to the Cowboys. He did not practice Wednesday and Steelers coach Mike Tomlin says he will not play against the Raiders.

RB Jaylen Warren, Pittsburgh Steelers: Questionable (knee)

Warren missed the last two games with a knee injury but was back practicing Wednesday in a limited capacity. That improves his outlook for playing on Sunday, but later practices this week will be more telling.

RB Gus Edwards, Los Angeles Chargers: Questionable (ankle)

The Chargers' second-string running back is still recovering from an ankle injury suffered against the Chiefs in Week 4. He did not practice Wednesday and his status is still up in the air.

RB Jonathan Taylor, Indianapolis Colts: Questionable (ankle)

Taylor missed last week's game against the Jaguars and did not practice Wednesday. He said this latest ankle sprain isn't as bad as the one he had in 2022, giving some hope he can be back in Week 6. Thursday's practice will likely decide his status for the Colts' game against Tennessee this week.

QB Anthony Richardson, Indianapolis Colts: Questionable (oblique)

Richardson was out of the lineup for the Colts' Week 5 game with an oblique injury. He practiced in a limited fashion Wednesday and said he feels much better than last week.

WR Michael Pittman Jr., Indianapolis Colts: Questionable (back)

Pittman did not practice Wednesday due to a back injury. He's been dealing with that issue for most of the season so far and has yet to miss time.

WR Josh Downs, Indianapolis Colts: Questionable (toe)

Downs had a season-high in targets in Week 5 but did not practice Wednesday due to a toe injury suffered during the loss to the Jaguars.

WR DeVonta Smith, Philadelphia Eagles: Questionable (concussion)

Smith was a full-go in practice Wednesday. He needs to get cleared by the team's medical staff and an independent neurologist but looks on track to play for the first time since Week 3.

WR A.J. Brown, Philadelphia Eagles: Probable (hamstring)

Brown was a full participant in practice on Wednesday for the first time since Week 1. He should be back in the lineup for Week 6 against the Browns.

RB Nick Chubb, Cleveland Browns: Questionable (knee)

Chubb is back in practice this week as he works his way back from a knee injury he suffered last season. He was limited in practice all of last week and did not play, so it remains to be seen if that availability improves this week.

WR Rashid Shaheed, New Orleans Saints: Questionable (hip)

The Saints' leading receiver in yards and touchdowns did not practice Wednesday. There's no update yet on his status.

RB Alvin Kamara, New Orleans Saints: Questionable (hip/hand)

This marks the third week in a row that Kamara is listed on the report with hip and hand injuries. He did not practice Wednesday but played in Week 5 with the same injury designations.

RB Rhamondre Stevenson, New England Patriots: Questionable (foot)

Stevenson was benched to start Week 5 against the Dolphins but still managed 12 carries for 89 yards and a touchdown. He suffered what's been called a minor foot injury and missed practice on Wednesday.

RB Joe Mixon, Houston Texans: Questionable (ankle)

Mixon's been out since Week 2 with a right ankle injury but still leads the team in rushing yards. Texans coach DeMeco Ryans says his status is still up in the air. Mixon practiced on Friday last week in a limited fashion but did not practice Wednesday.

RB Dameon Pierce, Houston Texans: Questionable (hamstring)

Pierce has also missed the last three weeks with an injury but Ryans expects him to be back in action against the New England Patriots in Week 6.

WR Rashod Bateman, Baltimore Ravens: Questionable (groin)

Bateman had his best game of the year in Week 5 against Cincinnati but did not practice Wednesday due to injury.

RB Travis Etienne, Jacksonville Jaguars: Questionable (shoulder)

Etienne injured his shoulder late in Jacksonville's Week 5 win over Indianapolis and was limited in practice Wednesday. The Jaguars fly to London on Thursday for their overseas game against Chicago in Week 6.

K Jake Moody, San Francisco 49ers: Out (right ankle)

Moody injured his ankle during San Francisco's Week 5 loss to Arizona. He's expected to miss multiple games and the 49ers signed Matthew Wright to replace him this week.